The Use of Calquence for Treating Mantle Cell Lymphoma

Calquence for Treating Mantle Cell Lymphoma

If someone close to you is plagued with mantle cell lymphoma (MCL), doctors will
prescribe calquence
, which is a drug used to treat the condition. According to an article
published on, it is an essential medication for the treatment of
MCL because the kind of lymphoma is not easy to cure for many years. The cells grow very
fast compared to other kinds of lymphoma, and patients who are living with the disease
have not responded well with standard medications.

The FDA has approved the drug for individuals who had undergone at least another treatment, who were not cured or when the ailment relapsed in some patients. The drug is used as a targeted therapy that helps in blocking the proteins in the cancer cells, thus preventing them from dividing, lowering the growth of cancer. Read on to learn more.

Causes and symptoms of MCL

It is a kind of blood cancer occurring because of the abnormal and unrestrained growth of
lymphocytes. The ailment occurs in the form of Hodgkin and non-Hodgkin lymphoma
(NHL). As far as MCL is concerned, it is a B-cell NHL found in more women than men.
Cancerous cells lead to the growth of tumors in the human lymph nodes that enter the
bloodstream and keep spreading to the other lymph nodes. It affects the bone marrow as
well, spleen, liver, and digestive tract.

When it comes to the symptoms, they are swellings in the armpit, neck, loss of appetite,
groin swelling, weight loss, vomiting, nausea, night sweats, and fever. Records show that
about 3,300 new MCL cases are detected in the US every year.

How the drug works

Calquence has a selective inhibitor, BTK that unites covalently with cysteine remains found
in the BTK. The residue leads to the expansion and multiplication of the cancerous cells,
thus hindering the activity. The medication also activates the pathways needed for B-cell
proliferation, chemotaxis, adhesion, and trafficking. You will find the drug available in 60
numbers that come with 100 mg for oral use.

Clinical trials

The FDA approved the drug based on clinical trials. The study was conducted by including
124 adult individuals plagued with refractory MCL or relapsed conditions, and those who
had received at least one treatment previously. The results showed that 80 percent of the
patients using the drug attained an overall response, while 40 percent showed a full
response, and another 40 percent received a partial response. The average response time
was 1.9 months. Based on these findings the FDA approved Calquence for treating MCL.

Side effects of the drug

The commonly found side effects include headaches, anemia, neutropenia, and low blood
count, pain in the muscles, diarrhea, bruising, myalgia, fatigue, and thrombocytopenia.
Since every medication comes with side effects, calquence is no exception to the fact.


If one of your loved people witnesses any of these symptoms, consult with a medical
professional right away. There is no point in delaying thinking that the side effects will
wane in some time. Seeking medical attention is necessary if the side effects cause too
much discomfort in the patient.

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